Overcoming endocrine therapy resistance in breast cancer, a cat and mouse game?
نویسندگان
چکیده
منابع مشابه
Overcoming Resistance to Endocrine Therapy in Breast Cancer: New Approaches to a Nagging Problem
In the majority of women, breast cancer progresses through increased transcriptional activity due to over-expressed oestrogen receptors (ER). Therapeutic strategies include: (i) reduction of circulating ovarian oestrogens or of peripherally produced oestrogen (in postmenopausal women) with aromatase inhibitors and (ii) application of selective ER modulators for receptor blockade. The success of...
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In an admirably concise fashion, Dr.Pritchard summarizes the results of trials randomizing tens of thousands of women in order to evaluate various types and uses of endocrine treatment over more than 50 years. I would never have predicted these results when I began my medical career in the early 1970s, or even as late as 1984 when the first overviews of breast cancer therapy were performed by R...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2016
ISSN: 0923-7534
DOI: 10.1093/annonc/mdw455